Phenacetin (or acetophenetidin) is a pain-relieving and
Phenacetin is a phenylacetamide that was formerly used in
ANALGESICS but nephropathy and METHEMOGLOBINEMIA led to its
withdrawal from the market.
Phenacetin is a synthetic, white crystalline solid that is slightly
soluble in water and benzene, soluble in acetone and very soluble
PHYSICAL DESCRIPTION: Odorless fine white crystalline solid with a
lightly bitter taste. Used as an analgesic medicine.
Pharmaceutical raw material Phenacetin hot in Canada CAS 62-44-2
Appearance:white flash scaly crystalline powder
Phenacetin is a pain-relieving and fever-reducing drug,it is
metabolized as paracetamol (acetaminophen), which replaced it in
some over-the-counter medications following the ban on phenacetin.
Its analgesic effects are due to its actions on the sensory tracts
of the spinal cord. In addition, phenacetin has a depressant action
on the heart, where it acts as a negative inotrope. It is an
antipyretic, acting on the brain to decrease the temperature set
point. It is also used to treat rheumatoid arthritis (subacute
type) and intercostal neuralgia.
Those who have taken drugs that contain phenacetin are more likely
to develop cardiovascular disease, high blood pressure, anemia and
cancer, and they are at a higher risk of death because of renal
failure or diseases of the urinary system, according to various
studies. A 1989 study showed that daily users of phenacetin were
5.1 times more likely to develop kidney disease than people who
used the drug infrequently. The drug, which was also used in
veterinary medicine, was shown to cause benign and malignant tumors
in both mice and rats during experimental laboratory studies.
Some over-the-counter painkiller manufacturers replaced phenacetin
with paracetamol, a similar drug that has not been shown to be a
carcinogen. Paracetamol is also known as acetaminophen. Studies
have shown that acetaminophen also can cause damage to the kidneys,
but its side effects are not as serious as those of phenacetin.
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|Test Items||Specification||Test Results|
|Description||Should comply with the standard||Pass|
|Identification||Should be positive reaction||Pass|
|4-chloroacetanilide||Should comply with standard||Pass|
|Melting point||134℃ to 137℃||134℃ to 137℃|
|Conclusion||Complies with Enterprise Standard|